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Since the natural abundance of raspberry ketone is very low, it is prepared industrially by a variety of methods from chemical intermediates. One of the ways this can be done is through a crossed aldol-catalytic hydrogenation. In acetone and sodium hydroxide, 4-hydroxybenzaldehyde can form the a,-unsaturated ketone. This then goes through catalytic hydrogenation to produce raspberry ketone. This method produces a 99% yield.   Raspberry ketone is used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. It is one of the most expensive natural flavor components used in the food industry. The natural compound can cost as much as $20,000 per kg. Synthetic raspberry ketone is cheaper, with estimates ranging from a couple of dollars per pound to one fifth of the cost of natural product.
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Although products containing this compound are marketed for weight loss, there is no clinical evidence for this effect in humans.[10] The average estimated daily intake of dietary raspberry ketone has been estimated to be 0.42 mg/kg/day.[11] Early studies in rats looking into the potential toxicity of raspberry ketone found no effects on the body weight of rats with doses up to 100 mg/kg, 238 times greater than the estimated intake for humans or 0.01% of body weight.[11] A more recent study demonstrated that when mice were fed very high doses of raspberry ketone, up to 20 g/kg, 2% of body weight or 4761 times greater than estimated human intake, there was a statistically significant prevention of high-fat-diet-induced elevation in body weight.[12] The high dose effect is reported to stem from the alteration of lipid metabolism, increasing norepinephrine-induced lipolysis and fatty acid oxidation in cultured adipocytes.[13]
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